Titrimetric Assay of Zolmitriptan in Non-Aqueous Medium

Based on the nitrogenous base or tertiary amine moiety in zolmitriptan (ZMT), an anti-migraine drug, two highly accurate and selective titrimetric methods are proposed for the determination of ZMT in bulk drug and pharmaceuticals. In these methods, the drug dissolved in glacial acetic acid, was titrated with acetous perchloric acid and end point determined either visually by using crystal violet indicator (method A) or potentiometrically by using combined glass-SCE electrode (method B). Both the methods are applicable over the concentration range of 1.0-10.0 mg of ZMT. Calculations are based on 1:1 molar ratio i.e., ZMT: HClO4, owing to the presence of one tertiary nitrogen atom. The procedures were applied to determine ZMT in its tablets and the results were found to be in good agreement with those obtained by the reference method. Associated pharmaceutical materials did not interfere. The precision results, expressed by inter-day and intra-day relative standard deviation values, were satisfactory (≤ 1.77%). Accuracy was satisfactory as well. The accuracy and reliability of the methods were further ascertained by recovery studies via standard addition technique with percent recoveries in the range 98.00 102.0 % with standard deviation of less than 0.15%.